Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level.

@article{Wang2011HistamineDD,
  title={Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level.},
  author={Ke-yong Wang and Akihide Tanimoto and Xin Yong Guo and Sohsuke Yamada and Shohei Shimajiri and Yoshitaka Murata and Yan Ding and Masato Tsutsui and Seiya Kato and Teruo Watanabe and Hiroshi Ohtsu and Ken-ichi Hirano and Kimitoshi Kohno and Yasuyuki Sasaguri},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 4},
  pages={800-7}
}
OBJECTIVE Histamine and histamine receptors are found in atherosclerotic lesions, and their signaling and subsequent proatherogenic or proinflammatory gene expression are involved in atherogenesis. In the present study, we generated apolipoprotein E (apoE) and histamine synthesizing histidine decarboxylase double knockout (DKO) mice on a C57BL/6J (wild-type mice) background to clarify the roles of histamine in atherosclerosis. METHODS AND RESULTS Wild-type, apoE knockout (KO), and DKO mice… CONTINUE READING
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