Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP.

@article{Jarajapu2006HistamineDM,
  title={Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP.},
  author={Yagna P. R. Jarajapu and Charlotte A. Oomen and Victor V. Uteshev and Harm J. Knot},
  journal={European journal of pharmacology},
  year={2006},
  volume={547 1-3},
  pages={116-24}
}
The effect of histamine on the pressure-induced constriction was characterized in rat cerebral arteries and mechanisms were investigated. Rat cerebral arteries were pressurized to 70 mm Hg in an arteriograph and the effect of histamine on myogenic tone was studied. Histamine and amthamine, a selective histamine H(2)-receptor agonist, concentration-dependently decreased myogenic tone, which was unchanged in the absence of endothelium. 2-(2-aminoethyl) pyridine, a selective histamine H(1… CONTINUE READING