Histamine as an autocrine growth factor: an unusual role for a widespread mediator.

@article{Rivera2000HistamineAA,
  title={Histamine as an autocrine growth factor: an unusual role for a widespread mediator.},
  author={E. Silva Rivera and Graciela P. Cricco and Nicole Engel and Carlos Patricio Fitzsimons and George A. Martin and Rosa M. Bergoc},
  journal={Seminars in cancer biology},
  year={2000},
  volume={10 1},
  pages={15-23}
}
The involvement of histamine in cancer growth represents an old controversy and direct experimental evidence proving this hypothesis is not still available. In this paper we review the most relevant mechanisms referring to the role of histamine receptors, histidine decarboxylase and histamine release in the onset of an autocrine loop, that enables histamine to act as an autocrine growth factor. We postulate that this autocrine loop, that has been studied in an experimental mammary carcinoma… CONTINUE READING

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