Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells

@article{Lampiasi2007HistamineAS,
  title={Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells},
  author={Nadia Lampiasi and Antonina Azzolina and Giuseppe Montalto and Melchiorre Cervello},
  journal={Experimental & Molecular Medicine},
  year={2007},
  volume={39},
  pages={284-294}
}
The role of mast cells in tumor growth is still controversial. In this study we analyzed the effects of both histamine and pre-formed mediators spontaneously released by mast cells on the growth of two human hepatocellular carcinoma cell lines, HA22T/VGH and HuH-6, with different characteristics of differentiation, biological behavior and genetic defects. We showed that total mast cell releasate, exocytosed granules (granule remnants) and histamine reduced cell viability and proliferation in… CONTINUE READING

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