Histamine and its receptors.

  title={Histamine and its receptors.},
  author={Michael E Parsons and C. Robin Ganellin},
  journal={British journal of pharmacology},
  volume={147 Suppl 1},
This article reviews the development of our knowledge of the actions of histamine which have taken place during the course of the 20th century. Histamine has been shown to have a key physiological role in the control of gastric acid secretion and a pathophysiological role in a range of allergic disorders. The synthesis of, and pharmacological studies on, selective agonists and antagonists has established the existence of four types of histamine receptor and histamine receptor antagonists have… CONTINUE READING
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