Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis

@article{JadidiNiaragh2010HistamineAH,
  title={Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis},
  author={Farhad Jadidi-Niaragh and Abbas Mirshafiey},
  journal={Neuropharmacology},
  year={2010},
  volume={59},
  pages={180-189}
}

Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis

Evidence of the complex and controversial role of histamine in the pathogenesis of MS and EAE is reviewed and the therapeutic potential of histaminergic ligands in the treatment of autoimmune diseases is evaluated.

The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation.

How a long-standing molecule with previously recognized immunomodulatory and neuroprotective functions, histamine, might still provide a renewed and far-reaching role in MS is reported on.

Central Nervous System Anti-Inflammatory Responses within the Regulatory Cell Frequency and Facilitates Receptor Optimizes T 4 Histamine H

Compared with wild-type mice, animals with a disrupted Hrh4 (H 4 RKO) develop more severe myelin oligodendrocyte glycoprotein (MOG) 35–55 -induced experimental allergic encephalomyelitis and Mechanistically, it is shown that H 4 R plays a role in determining the frequency of T regulatory cells in secondary lymphoid tissues, and regulates T R cell chemotaxis and suppressor activity.

Histamine H4 Receptor Optimizes T Regulatory Cell Frequency and Facilitates Anti-Inflammatory Responses within the Central Nervous System

It is shown that, compared with wild-type mice, animals with a disrupted Hrh4 (H4RKO) develop more severe myelin oligodendrocyte glycoprotein (MOG)35\x{2013}55-induced experimental allergic encephalomyelitis and the lack of H4R leads to an impairment of an anti-inflammatory response.

Serum levels of histamine and diamine oxidase in multiple sclerosis.

The research team found significant low levels of histamine and diamine oxidase in RRMS patients; however the pathogenesis of this issue was unclear.

Type 2 Inflammatory Responses in Autoimmune Demyelination of the Central Nervous System: Recent Advances

The most recent developments showing the involvement of type 2 inflammatory components in CNS autoimmunity are summarised and possible lines of further investigation are discussed.

The Role of Autoantibodies in Diagnosis of Multiple Sclerosis

The most significant autoantibodies which could be used as biomarkers for diagnosis, prognosis and treatment in MS are discussed and the hope is that biomarkers speed up the MS monitoring.

Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells

The treatment of immethridine was used to treat Experimental autoimmune encephalomyelitis (EAE) and its therapeutic effect was evaluated, showing that the treatment ofimmethridines could alleviate EAE.

New kid on the block: does histamine get along with inflammation in amyotrophic lateral sclerosis?

Results from amyotrophic lateral sclerosis (ALS) patients and pre-clinical studies strongly suggest that systemic and CNS-intrinsic immune activation plays a central role in ALS pathogenesis.

Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis

Possible roles of gastric acid inhibitors on immunopathogenic mechanisms associated with multiple sclerosis are reviewed.
...

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