Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions

@article{Rapanelli2016HistamineAH,
  title={Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions},
  author={Maximiliano Rapanelli and Christopher Pittenger},
  journal={Neuropharmacology},
  year={2016},
  volume={106},
  pages={85-90}
}

Tables from this paper

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References

SHOWING 1-10 OF 85 REFERENCES
The human histaminergic system in neuropsychiatric disorders
The histamine H3 receptor: an attractive target for the treatment of cognitive disorders
TLDR
The purpose of this review is to acquaint the reader with the current understanding of H3 receptor localization and function as a modulator of neurotransmitter release and its effects on cognitive processes, as well as to provide an update on selected H3 antagonists in various states of preclinical and clinical advancement.
Histamine H3 antagonists as wake-promoting and pro-cognitive agents.
TLDR
Recent efforts towards the identification and pharmacological characterization of novel histamine H3 antagonists will be discussed.
Randomized Clinical Study of a Histamine H3 Receptor Antagonist for the Treatment of Adults with Attention-Deficit Hyperactivity Disorder
TLDR
Bavisant is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
Interactions of the histamine and hypocretin systems in CNS disorders
TLDR
The role of the histamine and hypocretin systems in sleep–wake modulation is reviewed and the possibility that narcolepsy-associated histamine abnormalities could mediate or result from the same processes that cause the hypocrretin cell loss is discussed.
Recent advances in histamine H3 receptor antagonists/inverse agonists
TLDR
Several H3R antagonists/inverse agonists appear to be promising drug candidates, including at least 15 compounds undergoing evaluation in clinical development, especially interesting is pitolisant, which is progressing through to Phase III clinical trials.
Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models.
Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse
TLDR
Whether the H3R inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits.
Support of the histaminergic hypothesis in Tourette Syndrome: association of the histamine decarboxylase gene in a large sample of families
TLDR
The results provide strong support for the histaminergic hypothesis in TS etiology and point to a possible role of histamine pathways in neuronal development.
The histaminergic network in the brain: basic organization and role in disease
TLDR
This Review explores the possible roles of brain histamine in the mechanisms underlying multiple sclerosis and experimental autoimmune encephalitis.
...
...