Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

@article{Tuomisto1983HistamineAH,
  title={Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis},
  author={Leena M Tuomisto and Hannu Kilpel{\"a}inen and Paavo Riekkinen},
  journal={Agents and Actions},
  year={1983},
  volume={13},
  pages={255-257}
}
The CSF of twenty-six patients with multiple sclerosis (MS) and of twelve control persons was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in patients with remitting and progressive type of disease the histamine level was about 60% higher than in the controls. On the other hand in both groups of patients the HMT activity was significantly lower (32% and 40% respectively) than that of controls. These results suggest an altered histamine metabolism in MS. This… CONTINUE READING
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