Histamine and antihistamines in atopic dermatitis.

  title={Histamine and antihistamines in atopic dermatitis.},
  author={Joerg Buddenkotte and Marcus Maurer and Martin S Steinhoff},
  journal={Advances in experimental medicine and biology},
Itching (pruritus) is perhaps the most common symptom associated with inflammatory skin diseases and can be a lead symptom ofextracutaneous disease (e.g., malignancy, infection, metabolic disorders). In atopic dermatitis itching sensations constitute one of the most prominent and distressing features. The most characteristic response to itching is the scratch reflex: a more or less voluntary, often sub-conscious motor activity, to counteract the itch by slightly painful stimuli. The benefit of… CONTINUE READING