Histamine- and acetylcholine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats.


Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats were given saline, histamine (1.25, 2.5 or 5.0 micrograms/kg) or acetylcholine (1.0 or 2.0 micrograms/kg). Both agents caused a dose-dependent decrease in blood pressure which was greater in the spontaneously hypertensive animals. The permeability of the blood brain-barrier was measured with 131I… (More)


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