Histamine <ce:italic>N</ce:italic>-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

@article{Palada2012HistamineT,
  title={Histamine <ce:italic>N</ce:italic>-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease},
  author={Vinko Palada and Julijana Terzi{\'c} and Joseph R Mazzulli and Grace Bwala and Dimitri Krainc},
  journal={Neurobiology of Aging},
  year={2012},
  volume={33},
  pages={836.e1-836.e3}
}
Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased… CONTINUE READING
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