Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes.

@article{Chen2003HistamineNG,
  title={Histamine N-methyltransferase gene polymorphisms in Chinese and their relationship with enzyme activity in erythrocytes.},
  author={Guo-Lin Chen and Haijian Wang and Wei Wang and Zhen-hua Xu and Gan Zhou and Fuchu He and Hong-hao Zhou},
  journal={Pharmacogenetics},
  year={2003},
  volume={13 7},
  pages={389-97}
}
The aim of this study was to identify polymorphisms in the histamine N-methyltransferase (HNMT) gene in Chinese and to assess their relationship with HNMT activity. One hundred and ninety-two unrelated subjects were recruited. HNMT polymorphisms were screened by direct sequencing with purified polymerase chain reaction products comprising all six exons, plus splice junctions, as well as approximately 2 kb of the 5'-flanking region (5'-FR). Erythrocyte HNMT activity was previously measured by… CONTINUE READING

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