Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells

  title={Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells},
  author={Claudia L. Hofstra and Pragnya J. Desai and Robin L. Thurmond and Wai-Ping Fung-Leung},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1212 - 1221}
The diverse physiological functions of histamine are mediated through distinct histamine receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells are currently unclear. The present study shows that histamine induces chemotaxis of mouse mast cells, without affecting mast cell degranulation. Mast cell chemotaxis toward histamine could be blocked by the dual H3/H4 receptor antagonist thioperamide, but not by H1 or H2 receptor antagonists. This chemotactic… 

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