Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells

@article{Hofstra2003HistamineHR,
  title={Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells},
  author={Claudia L. Hofstra and Pragnya J. Desai and Robin L. Thurmond and Wai-Ping Fung-Leung},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={305},
  pages={1212 - 1221}
}
The diverse physiological functions of histamine are mediated through distinct histamine receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells are currently unclear. The present study shows that histamine induces chemotaxis of mouse mast cells, without affecting mast cell degranulation. Mast cell chemotaxis toward histamine could be blocked by the dual H3/H4 receptor antagonist thioperamide, but not by H1 or H2 receptor antagonists. This chemotactic… 

Figures and Tables from this paper

Histamine H4 receptor mediates chemotaxis of human lung mast cells

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

TLDR
Using specific histamine receptor ligands, this work has provided a definitive proof that the H4 receptor mediates eosinophil chemotaxis, cell shape change and upregulation of adhesion molecules.

Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H4 Receptor–Mediated Chemotaxis of Mast Cells

TLDR
It is shown that histamine induced Rac GTPase activation via the H4 receptor, and inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) by LY294002 suppressed the histamine-induced chemotaxis and activation of Rac G TPases, suggesting that PI3K regulates Chemotaxis upstream of Rac activation.

Human skin mast cells express H2 and H4, but not H3 receptors.

TLDR
The data show that human mast cells constitutively express primarily H2 and H4 receptors and that H2 receptors are functionally linked to cellular processes, and provide new insights into the mechanisms that govern auto- and paracrine histamine-induced mast cell functions.

Histamine Release from Mast Cells and Basophils.

TLDR
The in-depth knowledge of mast cell and basophil histamine release and its biologic effects is poised to uncover new therapeutic avenues for a wide spectrum of disorders.

Histamine synthesis is required for granule maturation in murine mast cells

TLDR
It is suggested that histamine promotes granule maturation in mast cells and acts as an proinflammatory mediator.

Histamine H4 Receptor mediates interleukin-8 and TNF-α release in human mast cells via multiple signaling pathways.

TLDR
It is found that H4R mediates the release of inflammatory cytokine TNF-α and chemokine IL-8 in human mast cells via PI3K, Ca2+-Calcineurin-NFAT and MAPKs signaling pathways.

Critical Role of Histamine H4 Receptor in Leukotriene B4 Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo

TLDR
Reduced levels of the neutrophil chemattractant leukotriene B4 were observed upon pretreatment with thioperamide, providing a mechanistic explanation for the prevention of neutrophilia by H4 receptor antagonism.
...

References

SHOWING 1-10 OF 41 REFERENCES

Possible participation of histamine H3-receptors in the regulation of anaphylactic histamine release from isolated rat peritoneal mast cells.

TLDR
It is strongly suggested that histamine H3-like receptors are largely responsible for the negative feedback regulation of the anaphylactic histamine release from rat peritoneal mast cells.

Histamine inhibits tumor necrosis factor alpha release by mast cells through H2 and H3 receptors.

  • E. Bissonnette
  • Biology, Medicine
    American journal of respiratory cell and molecular biology
  • 1996
TLDR
It is suggested that histamine may act as an autocrine regulator of cytokine release by mast cells and thus modulate inflammatory responses in allergic asthma.

Gi-Mediated Activation of the Syk Kinase by the Receptor Mimetic Basic Secretagogues of Mast Cells: Role in Mediating Arachidonic Acid/Metabolites Release1

TLDR
The results suggest that in the nonimmunological, Gi-mediated pathway, Syk is located downstream from phospholipase C and phosphatidylinositol 3-kinase, however, in common with the FcεRI- mediated pathway, activation of Syk by c48/80 is dependent on a src-like protein tyrosine kinase.

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

TLDR
It is reported that histamine enhances TH1-type responses by triggering the histamine receptor type 1 (H1R), whereas bothTH1- and TH2- type responses are negatively regulated by H2R through the activation of different biochemical intracellular signals.

Cloning and functional expression of the human histamine H3 receptor.

TLDR
A directed effort to discover novel G protein-coupled receptors through homology searching of expressed sequence tag databases identified a partial clone (GPCR97) that had significant homology to biogenic amine receptors.

Pituitary Adenylate Cyclase Activating Polypeptide Induces Degranulation of Rat Peritoneal Mast Cells via High‐Affinity PACAP Receptor‐Independent Activation of G Proteins

TLDR
It is concluded that PACAP exerts a secretory effect in RPMCs by high‐affinity PACAP receptor‐independent direct activation of one or more G proteins, which may then activate the PLC‐dependent signal‐transduction pathway.

Stem cell factor-induced migration of mast cells requires p38 mitogen-activated protein kinase activity.

TLDR
This is the first report of a physiological function of SCF-dependent activation of p38, and whether p38-mediated mast cell migration is a possible target for suppression of mast cell hyperplasia remains to be determined.

Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes*

TLDR
The molecular cloning and characterization of a novel orphan G-protein-coupled receptor named GPRv53 was obtained through a search of the human genomic DNA data base and analyzed by rapid amplification of cDNA ends (RACE).

Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.

TLDR
GPCR105 is a novel histamine receptor structurally and pharmacologically related to the H(3) receptor, and may be a therapeutic target for the regulation of immune function, particularly with respect to allergy and asthma.