Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata.

@article{Threlfell2004HistamineHR,
  title={Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata.},
  author={Sarah Threlfell and Stephanie J Cragg and Imre Kall{\'o} and Gergely F. T{\'u}ri and Clive W. Coen and Susan A. Greenfield},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 40},
  pages={8704-10}
}
The substantia nigra pars reticulata (SNr) plays a key role in basal ganglia function. Projections from multiple basal ganglia nuclei converge at the SNr to regulate nigrothalamic output. The SNr is also characterized by abundant aminergic input, including dopaminergic dendrites and axons containing 5-hydroxytryptamine (5-HT) or histamine (HA). The functions of HA in the SNr include motor control via HA H3 receptors (H3Rs), although the mechanism remains far from elucidated. In Parkinson's… CONTINUE READING

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