Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex

  title={Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex},
  author={Eberhard Schlicker and Roland Betz and Manfred G{\"o}thert},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Rat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing citalopram, an inhibitor of serotonin uptake) and the effect of histamine on the electrically (3 Hz) evoked 3H overflow was studied. Histamine decreased the evoked overflow in a concentration-dependent manner. The inhibitory effect of histamine was antagonized by impromidine and burimamide, but was not affected by pheniramine, ranitidine, metitepine and phentolamine. Given alone… CONTINUE READING
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