Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

@article{Sadek2016HistamineHR,
  title={Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases},
  author={Bassem Sadek and Ali Saad and Adel Shaban Sadeq and Fakhreya Yousuf Jalal and Holger Stark},
  journal={Behavioural Brain Research},
  year={2016},
  volume={312},
  pages={415-430}
}
  • B. Sadek, A. Saad, H. Stark
  • Published 1 October 2016
  • Psychology, Biology, Medicine
  • Behavioural Brain Research
View on Elsevier
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93 Citations
Highly Influential Citations
2
Background Citations
24
Methods Citations
3
Results Citations
2

93 Citations

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Citation Type

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The findings from animal and clinical epilepsy research on the role of brain histamine and its receptors are summarized and current gaps in the research are identified.
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The observed results suggested a possible contribution of H3Rs in the alteration of brain neurotransmitters that accompany neurodegenerative diseases, such as AD.
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An analysis of the reciprocal influences of neurons involved in the rapid-eye-movement phase of sleep (REM sleep) under the conditions of changes in the concentrations of various neuromodulators that are characteristic of Alzheimer’s disease shows that the treatment with the antagonists of orexin receptors is not appropriate.
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TLDR
The initial overall results observed in an idiopathic ASD mice model show that E100 alleviated the assessed behavioral deficits and demonstrate that simultaneous targeting of brain histaminergic and cholinergic neurotransmissions is crucial for palliation of ASD-like features, albeit further in vivo assessments on its effects on brain levels of ACh as well as HA are still needed.
QSAR Modeling of Histamine H3R Antagonists/inverse Agonists as Future Drugs for Neurodegenerative Diseases
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