Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.

@article{FernndezDueas2010HistamineHR,
  title={Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.},
  author={V{\'i}ctor Fern{\'a}ndez-Due{\~n}as and Francisco Ciruela and Jorge Gand{\'i}a and Silvia M S{\'a}nchez and Eul{\`a}lia Planas and Raquel Poveda},
  journal={European journal of pharmacology},
  year={2010},
  volume={638 1-3},
  pages={72-7}
}
Opioids provide effective analgesia in adult patients with painful inflammatory diseases. The proposed mechanism of action is the activation of peripheral opioid receptors, which may be up-regulated in such conditions. Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of… CONTINUE READING

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