Histamine H3 antagonists as wake-promoting and pro-cognitive agents.

@article{Stocking2008HistamineHA,
  title={Histamine H3 antagonists as wake-promoting and pro-cognitive agents.},
  author={Emily M. Stocking and Michael A Letavic},
  journal={Current topics in medicinal chemistry},
  year={2008},
  volume={8 11},
  pages={
          988-1002
        }
}
The histamine H3 receptor is a pre-synaptic auto- and hetero-receptor that controls the release of histamine and a variety of other neurotransmitters in the brain. As such, modulation of the histamine H(3) receptor is expected to affect wake via control of the release of histamine and to affect cognition via regulation of several other neurotransmitters including acetylcholine and norepinephrine. Over the last several years numerous pre-clinical studies have shown that histamine H3 antagonists… CONTINUE READING
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