Histamine H1 receptors in human brain labelled with [3H]Doxepin

@article{Kanba1984HistamineHR,
  title={Histamine H1 receptors in human brain labelled with [3H]Doxepin},
  author={Shigenobu Kanba and Elliott Richelson},
  journal={Brain Research},
  year={1984},
  volume={304},
  pages={1-7}
}
Doxepin, a tricyclic antidepressant, is one of the most potent histamine H1 antagonists. Therefore, the binding of [3H]doxepin to human brain membranes was examined. Scatchard analysis revealed two distinct binding sites. The high-affinity binding site with a dissociation constant (KD +/- S.E.M.) of 3.1 +/- 0.3 X 10(-10) M was pharmacologically identified as histamine H1 receptors. Dissociation curves at low concentrations of [3H]doxepin were biphasic, suggesting several possibilities about the… 
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