Histamine H1 receptors in human brain labelled with [3H]Doxepin
@article{Kanba1984HistamineHR, title={Histamine H1 receptors in human brain labelled with [3H]Doxepin}, author={S. Kanba and E. Richelson}, journal={Brain Research}, year={1984}, volume={304}, pages={1-7} }
Doxepin, a tricyclic antidepressant, is one of the most potent histamine H1 antagonists. Therefore, the binding of [3H]doxepin to human brain membranes was examined. Scatchard analysis revealed two distinct binding sites. The high-affinity binding site with a dissociation constant (KD +/- S.E.M.) of 3.1 +/- 0.3 X 10(-10) M was pharmacologically identified as histamine H1 receptors. Dissociation curves at low concentrations of [3H]doxepin were biphasic, suggesting several possibilities about the… CONTINUE READING
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