Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers

@article{Sato2013HistamineHR,
  title={Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers},
  author={Hirotoshi Sato and C. Ito and M. Tashiro and K. Hiraoka and K. Shibuya and Y. Funaki and R. Iwata and H. Matsuoka and K. Yanai},
  journal={Psychopharmacology},
  year={2013},
  volume={230},
  pages={227-234}
}
RationaleHistamine H1 antagonists have hypnotic, appetite-promoting, and sedative effects. The affinities of various antidepressants for histamine receptors have only been partially determined in vitro and animal study. Positron emission tomography (PET) can clarify the in vivo dynamics of antidepressants at histamine receptors.ObjectivesWe performed human PET imaging with [11C]doxepin, a selective PET ligand of the histamine H1 receptor (H1R), to study the in vivo affinities of fluvoxamine and… Expand
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