Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans.

@article{Matsuda2004HistamineHA,
  title={Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans.},
  author={Naoyuki Matsuda and Subrina Jesmin and Yoshika Takahashi and Eiichiro Hatta and Masanobu Kobayashi and Kazuto Matsuyama and Nozomi Kawakami and Ichiro Sakuma and Satoshi Gando and Hiyoyuki Fukui and Yuichi Hattori and Roberto Levi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={309 2},
  pages={786-95}
}
Histamine is highly concentrated in the heart of animals and humans. Excessive release in pathophysiological conditions, such as immediate hypersensitivity and septic shock, causes cardiac dysfunction and arrhythmias. Previous pharmacological studies revealed that H(1) and H(2) receptors mediate these effects. Yet, an accurate estimate of the distribution and molecular characteristics of cardiac histamine receptors is missing. Recently, the genes encoding H(1) and H(2) receptors have been… CONTINUE READING

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