Histamine H1‐ and H2‐receptors in the central thermoregulatory pathways of the rat

@article{Green1975HistamineHA,
  title={Histamine H1‐ and H2‐receptors in the central thermoregulatory pathways of the rat},
  author={M. D. Green and B. Cox and Peter Lomax},
  journal={Journal of Neuroscience Research},
  year={1975},
  volume={1}
}
The effects of phyrilamine and burimamide (histamine H1‐ and H2‐receptor blockers, respectively) on the hypothermic response to histidine loading have been studied in rats. The antagonists were injected into one of three sites in the brain: the preoptic/anterior hypothalamic nuclei, the lateral ventricle, or the third ventricle. Only injections of burimamide into the third ventricle blocked the hypothermic response to systemic injection of histidine. Behavioral studies revealed that, after… Expand
The role of central histamine H1- and H2-receptors in hypothermia induced by histamine in the rat
TLDR
It is concluded that histamine induces hypothermia by lowering the set point of the hypothalamic thermostat by means of H1-receptors. Expand
ANALYSIS OF HISTAMINE RECEPTORS IN THE CENTRAL THERMOREGULATORY MECHANISM OF Mastomys natalensis
TLDR
It is concluded that both H1‐ and H2‐histamine receptors are present in the brain of Mastomys and the H1-receptors mediate hypothermia and H3‐receptor agonists hyperthermia. Expand
Histamine Influences Body Temperature by Acting at H1and H3 Receptors on Distinct Populations of Preoptic Neurons
TLDR
It is reported that histamine reduced the spontaneous firing rate of GABAergic preoptic neurons by activating H3 subtype histamine receptors, and this effect involved a decrease in the level of phosphorylation of the extracellular signal-regulated kinase and was not dependent on synaptic activity. Expand
Implication of prostaglandins and histamine H1 and H2 receptors in radiation-induced temperature responses of rats.
TLDR
The results of these studies suggest that the release of neurohumoral substances induced by exposure to ionizing radiation is dose dependent and has different consequences on physiological processes such as the regulation of body temperature. Expand
Histamine and the hypothalamus
TLDR
It is concluded that although there is good evidence now linking histamine and the hypothalamus more specific studies are required, for instance using microinjection or in vitro techniques and the more specific chemical tools now available, to enable a clearer understanding of the physiological role of histamine inThe hypothalamus. Expand
Sites and mechanisms of action of histamine in the central thermoregulatory pathways of the rat
TLDR
Behavioural thermoregulation studies indicated that the fall in temperature induced by systemic injection of histidine is due to activation of efferent heat loss pathways, which is blocked by injection of the H 2 -receptor antagonist, burimamide into the third ventricle. Expand
Analysis of hypothermic response to centrally administered histamine in pigeons.
TLDR
It is concluded that both H1- and H2-histamine receptors are present in the brain of pigeon and are responsible for H-induced hypothermia. Expand
Histamine and histamine receptors: behavioral thermoregulation in the salamander Necturus maculosus.
TLDR
Results from injections of HA H1-receptor agonist (2-pyridylethylamine) and antagonist (pyrilamine), and H2- receptor agonists (dimaprit) and antagonists (cimetidine) had significant effects on thermoregulation; H 1-receptors may mediate behavioral hyperthermia and H 2-receptionors behavioral hypothermia. Expand
The distribution of histamine H1-receptors in the rat brain: An autoradiographic study
TLDR
The localization of histamine H 1 -receptors in the rat brain was studied at the light microscopic level by quantitative autoradiography and revealed a widespread distribution of these receptors throughout the brain. Expand
Hypothalamic Neuronal Histamine Modulates Febrile Response but Not Anorexia Induced by Lipopolysaccharide
TLDR
Results suggest that hypothalamic neural HA is Involved in the IL-1ß-dominant pathway, rather than the TNF-α-Dominant pathway, preceding the systemic Inflammatory response induced by exogenous pyrogens, such as LPS. Expand
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