Corpus ID: 23059389

Histamine H-2 receptor stimulation and inhibition of pepsin secretion in the dog.

@article{Hirschowitz1981HistamineHR,
  title={Histamine H-2 receptor stimulation and inhibition of pepsin secretion in the dog.},
  author={B. Hirschowitz and J. Rentz and E. Molina},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1981},
  volume={218 3},
  pages={
          676-80
        }
}

B. Hirschowitz, J. Rentz, E. Molina

Published 1981

Chemistry, Medicine

The Journal of pharmacology and experimental therapeutics

Although low doses of histamine (less than 150 nM/kg.hr) stimulate pepsin secretion, higher doses inhibit pepsin secretion in a dose-dependent manner. To better histamine stimulation of pepsin, histamine was used at doses at the lower end of the dose-response scale in five dogs with gastric fistula. Five doses of histamine below the ED50 for acid, viz, 9, 22.5, 67.5, 90 and 112 nM/kg.hr in 45-min steps, provided values for pepsin secretion from which Ed50 = 11.4 nmol/kg.hr (i.e., about 1/12 the… CONTINUE READING

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