• Corpus ID: 29676128

Histamine H 2 Receptor Trafficking : Role of Arrestin , Dynamin , and Clathrin in Histamine H 2 Receptor Internalization

@inproceedings{Fernndez2008HistamineH2,
  title={Histamine H 2 Receptor Trafficking : Role of Arrestin , Dynamin , and Clathrin in Histamine H 2 Receptor Internalization},
  author={Natalia Cristina Fern{\'a}ndez and Federico Monczor and Alberto Baldi and Carlos Alberto Davio and Carina Shayo},
  year={2008}
}
Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist amthamine, besides promoting receptor desensitization, induced H2r internalization. We further studied the mechanisms involved and its potential role in receptor resensitization. In COS7 transfected cells, amthamine induced H2r time-dependent… 

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