Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation.

@article{Desai2011HistamineHR,
  title={Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation.},
  author={Pragnya Desai and Robin L. Thurmond},
  journal={European journal of immunology},
  year={2011},
  volume={41 6},
  pages={1764-73}
}
The histamine H(4) receptor (H(4)R) has been implicated in numerous inflammatory functions. Here it is shown that the receptor can mediate cytokine production from mast cells. Histamine and an H(4)R agonist, JNJ 28610244, induced the production of IL-6 in mouse bone marrow (BM)-derived mast cells. This effect was blocked by two different H(4)R antagonists and was not present in H(4)R-deficient cells. In addition, histamine acting via the H(4) R potentiated LPS-induced IL-6 production. Histamine… CONTINUE READING
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