Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors

@article{Zhuang2018HistamineES,
  title={Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors},
  author={Qian-Xing Zhuang and Han-Ting Xu and Xu-Juan Lu and Bin Li and Wing-ho Yung and Jian-jun Wang and Jing-Ning Zhu},
  journal={Molecular Neurobiology},
  year={2018},
  volume={55},
  pages={8059-8070}
}
The central histaminergic nervous system, originating from the tuberomammillary nucleus (TMN) of the hypothalamus, widely innervates almost the whole brain, including the basal ganglia. Intriguingly, the histaminergic system is altered in parkinsonian patients. Yet, little is known about the effect and mechanisms of histamine on different types of neurons in the basal ganglia circuitry. Here, by using anterograde tracing, immunostaining, patch clamp recording, and single-cell qPCR techniques… CONTINUE READING
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