Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model

@article{Zhou2018Histamine4RA,
  title={Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model},
  author={Pei Zhou and Judith R Homberg and Qiuyuan Fang and Jiaqi Wang and Chunqing Liu},
  journal={Brain, Behavior, and Immunity},
  year={2018},
  volume={76},
  pages={61-73}
}
The activation of microglial cells is presumed to play a key role in the pathogenesis of Parkinson's disease (PD). The activity of microglia is regulated by the histamine-4 receptor (H4R), thus providing a novel target that may prevent the progression of PD. However, this putative mechanism has so far not been validated. In our previous study, we found that mRNA expression of H4R was upregulated in PD patients. In the present study, we validated this possible mechanism using the rotenone… CONTINUE READING
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