Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model.

@article{Morgan2007Histamine4R,
  title={Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model.},
  author={Ross K. Morgan and Brian P McAllister and Lillian Cross and Daniel S. Green and Hardy Kornfeld and David M. Center and William W. Cruikshank},
  journal={Journal of immunology},
  year={2007},
  volume={178 12},
  pages={8081-9}
}
Histamine has an important role in regulation of immune response which is mediated by differential expression of four distinct receptors, H1R-H4R. H1R and HR2 have previously been shown to be involved with modulation of lung inflammation. H4R is also expressed on inflammatory cells; therefore, we investigated the potential role of H4R in development of allergic asthma in a murine model. We determined that the H4R agonist 4-methylhistamine when delivered intratracheally before Ag challenge… CONTINUE READING

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