Histamine‐N‐methyl transferase polymorphism and risk for multiple sclerosis

@article{GarcaMartn2010HistamineNmethylTP,
  title={Histamine‐N‐methyl transferase polymorphism and risk for multiple sclerosis},
  author={E. Garc{\'i}a-Mart{\'i}n and C. Martı́nez and J. Benito-Le{\'o}n and P. Calleja and M. D{\'i}az-S{\'a}nchez and D. Pisa and H. Alonso-Navarro and L. Ayuso-Peralta and D. Torrecilla and J. A. Ag{\'u}ndez and F. Jim{\'e}nez-Jim{\'e}nez},
  journal={European Journal of Neurology},
  year={2010},
  volume={17}
}
  • E. García-Martín, C. Martı́nez, +8 authors F. Jiménez-Jiménez
  • Published 2010
  • Medicine
  • European Journal of Neurology
  • Background:  Histamine N‐methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis‐MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that causes the amino acid substitution Thr105Ile (decreasing enzyme activity) and the risk for MS. 
    12 Citations

    Topics from this paper

    Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase.
    • 4
    Histamine N-Methyltransferase in the Brain
    • 5
    • PDF
    NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis
    • 8
    • PDF
    Histamine N-methyltransferase regulates aggression and the sleep-wake cycle
    • 15
    • PDF
    Ovarian transcriptomic signatures of zebrafish females resistant to different environmental perturbations.
    • 3
    • PDF

    References

    SHOWING 1-10 OF 24 REFERENCES
    Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis
    • 64
    Nonsynonymous Polymorphisms of Histamine-Metabolising Enzymes in Patients with Parkinson’s Disease
    • 30
    Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.
    • 131
    • PDF
    Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
    • 84
    • PDF
    Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis
    • 54
    • PDF
    A Key Regulatory Role for Histamine in Experimental Autoimmune Encephalomyelitis: Disease Exacerbation in Histidine Decarboxylase-Deficient Mice1
    • 72
    • PDF
    Transdermal histamine in multiple sclerosis: part one -- clinical experience.
    • 18
    A Pilot, Open Label, Clinical Trial Using Hydroxyzine in Multiple Sclerosis
    • 48
    • PDF
    Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis
    • 41
    Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients
    • 188