Histamine‐N‐methyl transferase polymorphism and risk for multiple sclerosis

  title={Histamine‐N‐methyl transferase polymorphism and risk for multiple sclerosis},
  author={E. Garc{\'i}a-Mart{\'i}n and C. Martı́nez and J. Benito-Le{\'o}n and P. Calleja and M. D{\'i}az-S{\'a}nchez and D. Pisa and H. Alonso-Navarro and L. Ayuso-Peralta and D. Torrecilla and J. A. Ag{\'u}ndez and F. Jim{\'e}nez-Jim{\'e}nez},
  journal={European Journal of Neurology},
  • E. García-Martín, C. Martı́nez, +8 authors F. Jiménez-Jiménez
  • Published 2010
  • Medicine
  • European Journal of Neurology
  • Background:  Histamine N‐methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis‐MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that causes the amino acid substitution Thr105Ile (decreasing enzyme activity) and the risk for MS. 
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