Hisactophilin, a histidine-rich actin-binding protein from Dictyostelium discoideum.

  title={Hisactophilin, a histidine-rich actin-binding protein from Dictyostelium discoideum.},
  author={Julia Scheel and Karl B Ziegelbauer and Thomas Kupke and Bruno Martin Humbel and Angelika A. Noegel and G{\"u}nther Gerisch and Michael Schleicher},
  journal={The Journal of biological chemistry},
  volume={264 5},
The purification, cloning, and complete cDNA-derived sequence of a 17-kDa protein of Dictyostelium discoideum are described. This protein binds to F-actin in a pH-dependent and saturable manner. It induces actin polymerization in the absence of Mg2+ or K+, and is enriched in the submembranous region of the amoeboid cells as indicated by immunofluorescence labeling of cryosections. The mRNA as well as the protein are present throughout growth and all stages of development. The protein is… CONTINUE READING


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