His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk.

@article{Ohnami2008His595TyrPI,
  title={His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk.},
  author={Shumpei Ohnami and Y Sato and Kimio Yoshimura and Sumiko Ohnami and Hiromi Sakamoto and Kazunori Aoki and Hideki Ueno and Masafumi Ikeda and Chigusa Morizane and Kazuaki Shimada and Yoshihiro Sakamoto and Minoru Esaki and Ikuo Saito and Hiroshi Hirose and Daizo Saito and Haruhiko Sugimura and Tomoo Kosuge and Takuji Okusaka and Teruhiko Yoshida},
  journal={Gastroenterology},
  year={2008},
  volume={135 2},
  pages={477-88}
}
BACKGROUND & AIMS This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis. METHODS First, 227 single nucleotide polymorphisms (SNPs) of 46 genes were genotyped on 198 cases and 182 controls. The SNPs, which showed a significant association, were further genotyped on additional samples to perform a joint analysis (total 317 cases… CONTINUE READING

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