Hirsutism and the effectiveness of spironolactone in its management

@article{McMullen1993HirsutismAT,
  title={Hirsutism and the effectiveness of spironolactone in its management},
  author={Grace McMullen and Andr{\'e} J. Van Herle},
  journal={Journal of Endocrinological Investigation},
  year={1993},
  volume={16},
  pages={925-932}
}

Topics from this paper

Drug utilization pattern during pregnancy in Nekemte referral hospital: a cross sectional study
TLDR
Many pregnant women were found using drugs during pregnancy in Nekemte referral hospital, including potentially harmful drugs, and there should be intensive assessment of pregnant women treatment in line with the US food and drug administration agency (FDA) risk category and locally operating regulations. Expand
Medical Treatment of Hirsutism in Women
TLDR
The use of a logical combination of different options has been shown to achieve a satisfactory result in most cases, since systemic therapy reduces hair growth in less than 50% of cases, hirsute women frequently require cosmetic measures. Expand
A Comparative Study of Diane‐35 plus Spironolactone and Diane ‐35 Plus Finasteride in Cases of Hirsutism and Acne
TLDR
Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne and it is recommended that the treatment period be over 12 months. Expand
Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne.
TLDR
There is some evidence to show that spironolactone is an effective treatment to decrease the degree of hirsutism but there was no evidence for effectiveness for the treatment of acne vulgaris. Expand
Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: A randomised controlled study
TLDR
Flutamide and spironolactone plus CPA/EE are effective drugs in the treatment of hirsutism and total cholesterol levels decreased significantly but no significant change was observed in any other lipid parameters or in the patients’ hormone profiles. Expand
Letter by Pascual-Figal et al regarding article, "Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival".
TLDR
It is shown that anabolic hormone deficiency is common in heart failure (HF) patients and the proportion of patients treated with spironolactone, a steroid chemically related to the mineralocorticoid aldosterone, which acts as an antiandrogen that competes with dihydrotestosterone at the androgen-receptor level, is low. Expand
TRATAMIENTO DEL SÍNDROME DE OVARIO POLIQUÍSTICO. ANTIANDRÓGENOS
A C E T A T O D E C I P R O T E R O N A El a c e t a t o de c i p r o t e r o n a es un e s t e r o i d e d e r i v a d o de la 17 a h i d r o x i p r o g e s t e r o n a con acc ion p r o g e s t aExpand
Hyperandrogenic chronic anovulation and psychologic disturbances
Os autores fazem uma revisao da sindrome dos ovarios policisticos (SOP) com relacao aos seus aspectos etiopatogenicos, clinicos, diagnosticos e terapeuticos, dando enfase aos transtornos de ordemExpand
Ovarian Suppression and Treatment of Hirsutism
TLDR
Electrolysis and laser photothermolysis appear to be the most effective cosmetic procedures, although the effects of these methods should not be considered permanent. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 61 REFERENCES
Comparison of sequential cyproterone acetate/estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism.
TLDR
It is concluded that spironolactone and CPA, in the dosages used in this study, are effective and well tolerated agents for the treatment of hirsutism, and that neither drug demonstrates a particular advantage over the other. Expand
Spironolactone: A Re-Examination
TLDR
Spironolactone is useful as a diuretic in conditions such as cirrhosis and congestive heart failure, and is most commonly employed because of its potassium- and magnesium-sparing qualities. Expand
The Hypothalamic Pulse Generator: The Reproductive Core
  • J. Veldhuis
  • Biology, Medicine
  • Clinical obstetrics and gynecology
  • 1990
TLDR
The availability of increasingly specific neurotransmitter probes and more penetrating neuroendocrine analytic tools should aid in further significant progress in these arenas and, therefore, ultimately help to delineate additional specific pathophysiologic mechanisms that subserve reproductive dysfunction in women. Expand
Absence of progestational activity of oral spironolactone.
TLDR
Findings suggest that spironolactone at clinically used dosages does not act as a progestin or an antiprogestin on the human endometrium. Expand
Androgens and estrogens in their negative feedback action in the hypothalamo-pituitary-testis axis: site of action and evidence of their interaction.
  • L. Gooren
  • Biology, Medicine
  • Journal of steroid biochemistry
  • 1989
TLDR
It was found that estrogen administration to agonadal men suppressed basal and LH-RH-stimulated LH levels and LH pulse amplitude while LH pulse frequency remained unaffected, and antiandrogens and antiestrogens evoked almost identical effects. Expand
Lack of effect of spironolactone on hair shaft diameter in hirsute females.
TLDR
The mean effect of spironolactone given over a 9 month period was to increase hair shaft diameter by +15% with 95% CI (-0.4% to +29%) and there were no changes in circulating serum androgen concentrations. Expand
Spironolactone Metabolism: Steady‐State Serum Levels of the Sulfur‐Containing Metabolites
TLDR
It was concluded that unmetabolized spironolactone is present in the serum and that the sulfur‐containing metabolite IV rather than canrenone is the major metabolite in serum following single or repeated doses of spironlactone. Expand
Spironolactone is an effective and well tolerated systemic antiandrogen therapy for Hirsute women.
TLDR
It is concluded that spironolactone is effective and well tolerated for hirsute women and caused objective changes in hair growth. Expand
Experimental studies on the endocrine side effects of new aldosterone antagonists.
TLDR
The results suggest that mespirenone seems to be a suitable candidate for development as a clinically useful aldosterone antagonist. Expand
Androgen and 19-norsteroid profiles in human preovulatory follicles from stimulated cycles: an isotope dilution-mass spectrometric study.
TLDR
The accumulation of 19-norsteroids in follicular fluid confirms that they are weakly active intermediates in the multistep enzymatic conversion of androgen to estrogen and it was confirmed that an estradiol/androstenedione concentration ratio above 20 is favourable for oocyte cleavage. Expand
...
1
2
3
4
5
...