Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study.

@article{Buehlmann2010HippocampusAI,
  title={Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study.},
  author={Eva Buehlmann and Gregor Emanuel Berger and Jacqueline Aston and Ute Gschwandtner and Marlon O. Pflueger and Stefan J. Borgwardt and Ernst-Wilhelm Radue and Anita Riecher-R{\"o}ssler},
  journal={Journal of psychiatric research},
  year={2010},
  volume={44 7},
  pages={447-53}
}
BACKGROUND Hippocampal volume (HV) reduction is well documented in schizophrenia. However, it is still unclear whether this change is a pre-existing vulnerability factor, a sign of disease progression, a consequence of environmental factors, such as drug use, antipsychotic medication, or malnutrition. The timing of HV changes is not well established, but a lack of macrostructural hippocampal brain abnormalities before disease onset would rather support a neuroprogressive illness model. AIM To… CONTINUE READING

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