Hippocampal vulnerability to stress and aging: possible role of neurotrophic factors

@article{Smith1996HippocampalVT,
  title={Hippocampal vulnerability to stress and aging: possible role of neurotrophic factors},
  author={M. Smith},
  journal={Behavioural Brain Research},
  year={1996},
  volume={78},
  pages={25-36}
}
  • M. Smith
  • Published 1996
  • Psychology, Medicine
  • Behavioural Brain Research
Chronic stress can accelerate age-related damage to the hippocampus. Adrenal glucocorticoids are thought to be responsible for this damage because of their ability to compromise energy metabolism and make neurons more vulnerable to glutamate excitotoxicity. Additional mechanisms by which stress or glucocorticoids could damage the hippocampus are considered in the context of recent evidence that stress regulates neurotrophic factor expression in the brain. Stress has been found to decrease brain… Expand
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