Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis

  title={Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis},
  author={Fu Lye M Woon and Shabnam Sood and Dawson W. Hedges},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
Smaller hippocampal volume as a vulnerability factor for the persistence of post-traumatic stress disorder
It is demonstrated for the first time that a smaller (left) hippocampus constitutes a risk factor for the persistence of PTSD.
Volume and shape analysis of the Hippocampus and amygdala in veterans with traumatic brain injury and posttraumatic stress disorder
The results suggest that the amygdala may be a neuroanatomical correlate in mediating PTSD-like symptoms in Veterans with TBI and alterations in the CA1 and subiculum subregions of hippocampus may have a role in depression and PTSD.
Grey matter reduction associated with posttraumatic stress disorder and traumatic stress
Decreased left hippocampal volumes in parents with or without posttraumatic stress disorder who lost their only child in China.
Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.
These results provide clear evidence of an association between a smaller amygdala volume and PTSD, and may trigger a renewed impetus for investigating structural differences in the amygdala, its genetic determinants, its environmental modulators, and the possibility that it reflects an intrinsic vulnerability to PTSD.
Does Hippocampal Volume in Patients with Posttraumatic Stress Disorder Vary by Trauma Type?
  • C. Hinojosa
  • Psychology, Biology
    Harvard review of psychiatry
  • 2022
Mixed-effects meta-analyses suggest that trauma type may moderate hippocampal volume in trauma-exposed individuals but not in those with PTSD.


Hippocampal volume in adult burn patients with and without posttraumatic stress disorder.
Evidence is provided that smaller hippocampal size in trauma-exposed individuals is a result of traumatic stress, and the posttraumatic application of NMDA antagonists may protect against hippocampal damage induced by traumatic stressors but increases the patient's risk of developing PTSD symptoms.
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
In monozygotic twins discordant for trauma exposure, it is found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology.
Smaller right hippocampus in war veterans with posttraumatic stress disorder
Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation
Previous findings of smaller hippocampal volume in PTSD are confirmed in a new population made up of out-patients who experienced different types of traumas, reducing co-morbidity to a minimum.
Hippocampal volume, PTSD, and alcoholism in combat veterans.
The failure to observe a strong association between PTSD and hippocampal volume in nonalcoholic subjects was not ascribable to younger age, reduced PTSD chronicity, or lower PTSD symptom severity, and the possibility that smaller hippocampusal volume is limited to groups in which PTSD is compounded by comorbid alcoholism is not necessarily incompatible with results suggesting a smaller hippocampus is predispositional to PTSD.
Structural Magnetic Resonance Imaging Findings in Posttraumatic Stress Disorder and Their Response to Treatment: A Systematic Review
This review evaluates and categorizes the research of hippocampal volume reduction in patients with PTSD, and considers the response of the hippo- campus to pharmacological intervention.