Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors

@article{Das2012HippocampalTO,
  title={Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors},
  author={Arabinda Das and Grant C Wallace and Christopher Holmes and Meryl L. McDowell and Naren Lal Banik},
  journal={Neuroscience},
  year={2012},
  volume={220},
  pages={237-246}
}
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Previous research has demonstrated several trends in human tissue that, undoubtedly, contribute to the development and progression of TLE. In this study we examined resected human hippocampus tissue for a variety of changes including gliosis that might contribute to the development and presentation of TLE. The study subjects consisted of six TLE patients and three sudden-death controls. Clinicopathological characteristics… CONTINUE READING

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