Hippocampal theta oscillations are travelling waves

@article{Lubenov2009HippocampalTO,
  title={Hippocampal theta oscillations are travelling waves},
  author={Evgueniy V. Lubenov and Athanassios G. Siapas},
  journal={Nature},
  year={2009},
  volume={459},
  pages={534-539}
}
Theta oscillations clock hippocampal activity during awake behaviour and rapid eye movement (REM) sleep. These oscillations are prominent in the local field potential, and they also reflect the subthreshold membrane potential and strongly modulate the spiking of hippocampal neurons. The prevailing view is that theta oscillations are synchronized throughout the hippocampus, despite the lack of conclusive experimental evidence. In contrast, here we show that in freely behaving rats, theta… 

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References

SHOWING 1-10 OF 64 REFERENCES
Patterns of hippocampal theta rhythm in the freely moving rat.
  • J. Winson
  • Biology
    Electroencephalography and clinical neurophysiology
  • 1974
Phase relationship between hippocampal place units and the EEG theta rhythm
TLDR
The phase was highly correlated with spatial location and less well correlated with temporal aspects of behavior, such as the time after place field entry, and the characteristics of the phase shift constrain the models that define the construction of place fields.
Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences
TLDR
Large‐scale parallel recordings are made use of to clarify and extend the finding that a cell's spike activity advances to earlier phases of the theta cycle as the rat passes through the cell's place field, and to show Granule cells of the fascia dentata are also modulated by theta.
INTRACELLULAR RECORDS FROM HIPPOCAMPAL PYRAMIDAL CELLS IN RABBIT DURING THETA RHYTHM ACTIVITY.
TLDR
The theta rhythm usually exists in unanesthetized animals and becomes prominent after various kinds of afferent stimulation or after stimulation of the midbrain reticular formation, and in this descriptive sense the hippocampal EEG bears an inverse relationship to the neocortical EEG.
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
TLDR
It is demonstrated that individual GABAergic interneurons can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at 4–7 Hz, and this GABAergic mechanism is sufficient to synchronize the firing of pyramsidal cells.
...
1
2
3
4
5
...