Hippocampal synaptic transmission and plasticity are preserved in myosin Va mutant mice.

@article{Schnell2001HippocampalST,
  title={Hippocampal synaptic transmission and plasticity are preserved in myosin Va mutant mice.},
  author={Eric Schnell and Roger A Nicoll},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 4},
  pages={1498-501}
}
Recent studies have identified myosin Va as an organelle motor that may have important functions in neurons. Abundantly expressed at the hippocampal postsynaptic density, it interacts with protein complexes involved in synaptic plasticity. It is also located in presynaptic terminals and may function to recruit vesicles in the reserve pool to the active zone. Dilute-lethal mice are spontaneous myosin Va mutants and have severe neurological symptoms. We studied hippocampal physiology at CA3-CA1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Myosin Va controls oligodendrocyte morphogenesis and myelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007
View 6 Excerpts
Highly Influenced

Functions of class V myosins in neurons.

The Journal of biological chemistry • 2013
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Class V myosins

TA RYAN
Biochim Biophys Acta • 2000

Identification of proteins in the postsynaptic density fraction by mass spectrometry

XH WANG, JQ ZHENG, MM POO
J Neurosci • 2000

Interaction of the postsynaptic density95 / guanylate kinase domainassociated protein complex with a light chain of myosinV and dynein

DM PREKERISRANDTERRIAN
J Neurosci • 2000

A role of actin filament in synaptic transmission and long-term potentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999

Brain myosinV , a calmodulincarrying myosin , binds to calmodulindependent protein kinase II and activates its kinase activity

RE CHENEY, M MATTEOLI, AA NASCIMENTO, PV DECAMILLI, RE LARSON
J Biol Chem • 1999

Inhibitors of myosin light chain kinase block synaptic vesicle pool mobilization during action potential firing.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 1 Excerpt

Similar Papers

Loading similar papers…