Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats.

@article{KalalianMoghaddam2013HippocampalSP,
  title={Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats.},
  author={Hamid Kalalian-Moghaddam and Tourandokht Baluchnejadmojarad and Mehrdad Roghani and Fatemeh Goshadrou and Abdolaziz Ronaghi},
  journal={European journal of pharmacology},
  year={2013},
  volume={698 1-3},
  pages={
          259-66
        }
}
Chronic diabetes mellitus initiates apoptosis and negatively affects synaptic plasticity in the hippocampus with ensuing impairments of learning and memory. Berberine, an isoquinoline alkaloid, exhibits anti-diabetic, antioxidant and nootropic effects. This study was conducted to evaluate the effect of berberine on hippocampal CA1 neuronal apoptosis, synaptic plasticity and learning and memory of streptozotocin (STZ)-diabetic rats. Long-term potentiation (LTP) in perforant path-dentate gyrus… CONTINUE READING
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