Hippocampal synaptic plasticity is modulated by theta rhythm in the fascia dentata of adult and aged freely behaving rats.

@article{Orr2001HippocampalSP,
  title={Hippocampal synaptic plasticity is modulated by theta rhythm in the fascia dentata of adult and aged freely behaving rats.},
  author={Gavin Orr and G S Aditya Rao and Frank P. Houston and Bruce L. McNaughton and C. A. Barnes},
  journal={Hippocampus},
  year={2001},
  volume={11 6},
  pages={647-54}
}
A modulatory role for the hippocampal theta rhythm in synaptic plasticity is suggested by the observations that theta occurs during exploratory behaviors, spatial learning is impaired when the theta rhythm is disrupted, and excitation of hippocampal principal cells is phase-coupled to the theta wave. The theta phase affects the nature of the plasticity induced in urethane-anesthetized rats and in the carbachol-treated in vitro slice preparation, but these oscillations are phenomenologically… CONTINUE READING

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