Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.

  title={Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.},
  author={Yukiko Asaka and Denis G M Jugloff and Liang Zhang and James H. Eubanks and Reiko Maki Fitzsimonds},
  journal={Neurobiology of disease},
  volume={21 1},
Rett syndrome is an X-linked neurodevelopmental disorder caused by mutations in the gene encoding the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2). Here we demonstrate that the Mecp2-null mouse model of Rett syndrome shows an age-dependent impairment in hippocampal CA1 long-term potentiation induced by tetanic or theta-burst stimulation. Long-term depression induced by repetitive low-frequency stimulation is also absent in behaviorally symptomatic Mecp2-null mice. Immunoblot… CONTINUE READING
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