Hippocampal synaptic plasticity as a biological substrate underlying episodic psychosis.

@article{Port1995HippocampalSP,
  title={Hippocampal synaptic plasticity as a biological substrate underlying episodic psychosis.},
  author={Robert Port and Kevin S. Seybold},
  journal={Biological psychiatry},
  year={1995},
  volume={37 5},
  pages={318-24}
}
Structural change in the hippocampal formation has become popular as a proposed neurobiological substrate for schizophrenic disorders. It is postulated that behavioral plasticity in the form of long-term potentiation of hippocampal synaptic transmission is an attractive putative mechanism for the mediation of transient psychosis. Moreover, the disturbed hippocampal neuroarchitecture found in schizophrenic brain may be susceptible to potentiation and dysfunctional to the degree that delusions… CONTINUE READING

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