Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia.

@article{Tepest2008HippocampalSA,
  title={Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia.},
  author={Ralf Tepest and Lei Wang and John G. Csernansky and Philip Neubert and Reinhard Heun and Lukas Scheef and Frank Jessen},
  journal={Dementia and geriatric cognitive disorders},
  year={2008},
  volume={26 4},
  pages={323-9}
}
BACKGROUND/AIMS Alzheimer's disease (AD) is preceded by prodromal states. To determine the neuroanatomical basis for the relationship among such states, we assessed surface conformations of the hippocampus in AD, mild cognitive impairment (MCI) and subjective memory impairment (SMI). METHODS Hippocampal surfaces were reconstructed three-dimensionally via large-deformation high-dimensional MRI brain mapping in 14 SMI, 15 MCI, 12 AD and 13 controls. The surfaces were divided a priori into… CONTINUE READING