Hippocampal structural changes across the menstrual cycle

@article{Protopopescu2008HippocampalSC,
  title={Hippocampal structural changes across the menstrual cycle},
  author={Xenia Protopopescu and Tracy Butler and Hong Pan and James C. Root and Margaret Altemus and Margaret Polanecsky and Bruce S. McEwen and David Silbersweig and Emily R. Stern},
  journal={Hippocampus},
  year={2008},
  volume={18}
}
Magnetic resonance imaging (MRI) in association with Jacobian‐modulated voxel‐based morphometry (VBM) was used to test for regional variation in gray matter over the menstrual cycle. T1‐weighted anatomical images were acquired using a spoiled gradient recalled acquisition sequence in 21 women. Each subject was scanned twice: once during the postmenstrual late‐follicular phase (Days 10–12 after onset of menses), and once during the premenstrual late‐luteal phase (1–5 days before the onset of… Expand
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References

SHOWING 1-10 OF 23 REFERENCES
Variations in sex-related cognitive abilities across the menstrual cycle
  • E. Hampson
  • Medicine, Psychology
  • Brain and Cognition
  • 1990
TLDR
The results provide qualified support for the hypothesis that the high levels of gonadal steroids present at the luteal phase of the cycle may facilitate skills favoring females, but be detrimental to skills favoring males. Expand
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
TLDR
Global grey matter volume decreased linearly with age, with a significantly steeper decline in males, and local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Expand
Is Cranial CSF Volume Under Hormonal Influence? An MR Study
TLDR
The CSF changes observed reflect a reduction in brain volume and do not support cerebral swelling as the cause of premenstrual neurological symptoms. Expand
Ovarian steroidal control of connectivity in the female hippocampus: An overview of recent experimental findings and speculations on its functional consequences
TLDR
The female hippocampus is optimized for different cognitive/behavioral functions when the female is sexually receptive and ovarian steroids levels are high rather than when she is not receptive and steroid levels are low, and shifts its optimal computational functions across the estrous/menstrual cycle. Expand
Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992 Oct;12(10):following table of contents]
  • CS Woolley, B. Mcewen
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992
TLDR
To the knowledge, this is the first demonstration of such short-term steroid-mediated synaptic plasticity occurring naturally in the adult mammalian brain. Expand
Preliminary evidence that estrogen protects against age-related hippocampal atrophy
TLDR
Findings suggest a neuroprotective effect of estrogen in postmenopausal women, as women subjects taking ERT had larger right hippocampal volumes than women subjects notTaking ERT and larger anterior hippocampalvolume than men subjects andWomen subjects not taking ERTs. Expand
Gray Matter Differences Correlate with Spontaneous Strategies in a Human Virtual Navigation Task
TLDR
Young healthy participants spontaneously use different strategies in a virtual radial maze, an adaptation of a task typically used with rodents, and data suggest that spatial strategies may provide protective effects against degeneration of the hippocampus that occurs with normal aging. Expand
Statistical parametric mapping of brain morphology: Sensitivity is dramatically increased by using brain-extracted images as inputs
TLDR
Using brain-extracted inputs eliminated the non-brain matter inclusions and the cortical gray matter exclusions, reducing the residual mean square errors (RMSEs) by over 30%. Expand
Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect
TLDR
Findings support a treatment duration dependent neuroprotective role of estrogen on HC volume in aging, particularly in women currently using estrogen therapy alone (ET). Expand
Role of estrogen in balancing contributions from multiple memory systems
  • D. Korol
  • Medicine, Psychology
  • Neurobiology of Learning and Memory
  • 2004
TLDR
This review discusses estrogen's actions on cognition within a memory systems framework, highlighting the work with a variety of paradigms showing that learning strategy is sensitive to estrogen even when learning rate is not. Expand
...
1
2
3
...