Hippocampal slices from prion protein null mice: disrupted Ca2+-activated K+ currents

@article{Colling1996HippocampalSF,
  title={Hippocampal slices from prion protein null mice: disrupted Ca2+-activated K+ currents},
  author={Simon B. Colling and John Collinge and John G. R. Jefferys},
  journal={Neuroscience Letters},
  year={1996},
  volume={209},
  pages={49-52}
}
The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP… CONTINUE READING

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