Hippocampal sharp waves: Their origin and significance

@article{Buzski1986HippocampalSW,
  title={Hippocampal sharp waves: Their origin and significance},
  author={Gy{\"o}rgy Buzs{\'a}ki},
  journal={Brain Research},
  year={1986},
  volume={398},
  pages={242-252}
}
  • G. Buzsáki
  • Published 29 November 1986
  • Biology
  • Brain Research
Spontaneous waves in the dentate gyrus of slices from the ventral hippocampus.
TLDR
Dentate waves were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats and it is hypothesized that dentate waves occur when spontaneous glutamate release from dentate afferents produces action potentials in neighboring granule cells that then summate electrotonically into a population event.
Origins of an Intrinsic Hippocampal EEG Pattern
TLDR
The results indicate that constitutive release from the mossy fiber terminal boutons regulates the incidence of SPWs and their contribution to information processing in hippocampus.
The hippocampal CA3 region can generate two distinct types of sharp wave‐ripple complexes, in vitro
TLDR
It is suggested that the hippocampus can generate dynamic changes in its activity stemming from the same excitatory and inhibitory circuits, and so, might provide the cellular and network basis for an input‐specific and activity‐dependent information transmission.
Title Origins of an Intrinsic Hippocampal EEG Pattern
TLDR
The results indicate that constitutive release from the mossy fiber terminal boutons regulates the incidence of SPWs and their contribution to information processing in hippocampus.
High-Frequency Oscillations in the Output Networks of the Hippocampal–Entorhinal Axis of the Freely Behaving Rat
TLDR
There is a powerful synchronization among the neuronal networks that connect the hippocampus to the neocortex during each hippocampal sharp wave, which biologically constrains theoretical models of hippocampal function and dysfunction and has the capacity to support an “off-line” memory consolidation process.
Selective activation of deep layer (V-VI) retrohippocampal cortical neurons during hippocampal sharp waves in the behaving rat
  • JJ Chrobak, G. Buzsáki
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
It is suggested that SPW-associated population bursts in hippocampal and retrohippocampal cortices exert a powerful depolarizing effect on their postsynaptic neocortical targets and may represent a physiological mechanism for memory trace transfer from the hippocampus to the neocortex.
Dentate EEG spikes and associated interneuronal population bursts in the hippocampal hilar region of the rat.
TLDR
It is suggested that dentate spike-associated synchronized bursts of hilar-region interneurons provide a suppressive effect on the excitability of the CA3-CA1 network in the intact brain.
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TLDR
The results are interpreted as suggesting that the granule cell membranes in the DG are relatively hyperpolarized during SAL compared with SWS as the result of either tonic excitatory bombardment occurring during SWS or tonic inhibitory bombardment during SAL.
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It is reported here that spontaneous firing of all the neurones recorded in the slice increased, consistent with the known effects of Ca2+ on membrane properties and synaptic transmission6–10, but the synchronous ‘field bursts’, and presumably their underlying mechanisms, were restricted to the population of pyramidal neurones in the hippocampal CA1 region.
Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat
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The present study re‐examines, with autoradiographic methods, the pattern of termination of fibers originating from various medio‐lateral divisions of the entorhinal cortex on dentate granule cells
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  • Biology
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TLDR
An orthodromically evoked late hyperpolarizing potential (LHP) was studied using intracellular recording techniques in rat hippocampal CA1 pyramidal cells in vitro and was not found to be dependent on the excitatory postsynaptic potential (EPSP).
Picrotoxin-induced epileptiform activity in hippocampus: role of endogenous versus synaptic factors.
TLDR
The pattern of observed changes indicated that PTX reduced inhibitory postsynaptic potential (IPSP) amplitudes, resulting in the appearance of repetitive (presumably recurrent) excitatory inputs.
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