Hippocampal seizures alter the expression of the pannexin and connexin transcriptome.

@article{Mylvaganam2010HippocampalSA,
  title={Hippocampal seizures alter the expression of the pannexin and connexin transcriptome.},
  author={Shanthini Mylvaganam and Liang Zhang and C. Peng Wu and Zhang Jane Zhang and Marina Samoilova and James Eubanks and Peter L. Carlen and Michael O Poulter},
  journal={Journal of neurochemistry},
  year={2010},
  volume={112 1},
  pages={92-102}
}
Some forms of seizure activity can be stopped by gap junctional (GJ) blockade. Here, we found that GJ blockers attenuate hippocampal seizure activity induced by a novel seizuregenic protocol using Co(2+). We hypothesized that this activity may occur because of the altered expression of connexin (Cx) and/or pannexin (Panx) mRNAs and protein. We found a 1.5-, 1.4-, and 2-fold increase in Panx1, Panx2, and Cx43 mRNAs, respectively. Significant post-translational modifications of the proteins Cx43… CONTINUE READING