Hippocampal sclerosis contributes to dementia in the elderly.

  title={Hippocampal sclerosis contributes to dementia in the elderly.},
  author={Jody Corey-Bloom and Marwan N. Sabbagh and Mark W. Bondi and Lawrence Arthur Hansen and Michael F Alford and Eliezer Masliah and Leon J. Thal},
  volume={48 1},
OBJECTIVE To assess the relevance of hippocampal sclerosis (HS) to dementia in the elderly. BACKGROUND HS is a prominent pathologic finding in some demented elderly, but the anatomic substrate and cognitive profiles of this dementia have not been well established. DESIGN/METHODS An autopsy series, including dot-immunobinding assay to estimate neocortical synaptic density, of eight patients (three men, five women) with HS on whom extensive antemortem neuropsychological testing was available… CONTINUE READING


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