Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease.

Abstract

Hippocampal precursor of nerve growth factor (proNGF)/NGF signaling occurs in conjunction with β-amyloid (Aβ) accumulations in Alzheimer disease (AD). To assess the involvement of this pathway in AD progression, we quantified these proteins and their downstream pathway activators in postmortem tissues from the brains of subjects with no cognitive impairment… (More)
DOI: 10.1097/NEN.0b013e318272caab

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@article{Mufson2012HippocampalPS, title={Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease.}, author={Elliott J. Mufson and Bin He and Muhammad Nadeem and Sylvia E. Perez and Scott Counts and S E Leurgans and Jason J Fritz and James J. Lah and Stephen D Ginsberg and Joanne Wuu and Stephen W. Scheff}, journal={Journal of neuropathology and experimental neurology}, year={2012}, volume={71 11}, pages={1018-29} }