Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task

@inproceedings{Tamura2017HippocampalprefrontalTC,
  title={Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task},
  author={Makoto Tamura and Timothy J. Spellman and Andrew M. Rosen and Joseph A Gogos and Joshua A. Gordon},
  booktitle={Nature Communications},
  year={2017}
}
  • Makoto Tamura, Timothy J. Spellman, +2 authors Joshua A. Gordon
  • Published in Nature Communications 2017
  • Medicine, Biology
  • Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta–slow gamma coupling between the hippocampus and medial prefrontal cortex (mPFC) is augmented in a genetic mouse model of cognitive dysfunction. This increased cross-frequency coupling is observed specifically when… CONTINUE READING

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